Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Smad2  SMAD family member 2   (Synonyms: 7120426M23Rik, Madh2, Madr2, Smad 2)
Results	Reference
1	J:282008 AlMegbel AM, Shuler CF, SMAD2 overexpression rescues the TGF-beta3 null mutant mice cleft palate by increased apoptosis. Differentiation. 2019 Oct 8;111:60-69
1	J:181099 Chen Z, Gao B, Zhou X, Expression patterns of histone acetyltransferases p300 and CBP during murine tooth development. In Vitro Cell Dev Biol Anim. 2012 Jan;48(1):61-8
1*	J:84447 Cui XM, Chai Y, Chen J, Yamamoto T, Ito Y, Bringas P, Shuler CF, TGF-beta3-dependent SMAD2 phosphorylation and inhibition of MEE proliferation during palatal fusion. Dev Dyn. 2003 Jul;227(3):387-94
1	J:96461 Cui XM, Shiomi N, Chen J, Saito T, Yamamoto T, Ito Y, Bringas P, Chai Y, Shuler CF, Overexpression of Smad2 in Tgf-beta3-null mutant mice rescues cleft palate. Dev Biol. 2005 Feb 1;278(1):193-202
1	J:169302 da Silva S, Hasegawa H, Scott A, Zhou X, Wagner AK, Han BX, Wang F, Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-{beta} signaling. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3395-400
1*	J:87407 Dudas M, Nagy A, Laping NJ, Moustakas A, Kaartinen V, Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev Biol. 2004 Feb 1;266(1):96-108
1	J:166902 Enomoto H, Nelson CM, Somerville RP, Mielke K, Dixon LJ, Powell K, Apte SS, Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation. Development. 2010 Dec;137(23):4029-38
1	J:332217 Feng J, Han X, Yuan Y, Cho CK, Janeckova E, Guo T, Pareek S, Rahman MS, Zheng B, Bi J, Jing J, Zhang M, Xu J, Ho TV, Chai Y, TGF-beta signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development. Elife. 2022 Dec 21;11
1	J:139005 Geske MJ, Zhang X, Patel KK, Ornitz DM, Stappenbeck TS, Fgf9 signaling regulates small intestinal elongation and mesenchymal development. Development. 2008 Sep;135(17):2959-68
1*	J:244781 Glover JD, Wells KL, Matthaus F, Painter KJ, Ho W, Riddell J, Johansson JA, Ford MJ, Jahoda CAB, Klika V, Mort RL, Headon DJ, Hierarchical patterning modes orchestrate hair follicle morphogenesis. PLoS Biol. 2017 Jul;15(7):e2002117
1	J:183603 Grieskamp T, Rudat C, Ludtke TH, Norden J, Kispert A, Notch signaling regulates smooth muscle differentiation of epicardium-derived cells. Circ Res. 2011 Apr 1;108(7):813-23
1	J:200638 Islam SS, Mokhtari RB, Kumar S, Maalouf J, Arab S, Yeger H, Farhat WA, Spatio-temporal distribution of Smads and role of Smads/TGF-beta/BMP-4 in the regulation of mouse bladder organogenesis. PLoS One. 2013;8(4):e61340
1*	J:203791 Kuracha MR, Siefker E, Licht JD, Govindarajan V, Spry1 and Spry2 are necessary for eyelid closure. Dev Biol. 2013 Nov 15;383(2):227-38
1	J:264609 Li J, Yuan Y, He J, Feng J, Han X, Jing J, Ho TV, Xu J, Chai Y, Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion. Dev Biol. 2018 Sep 1;441(1):191-203
1*	J:257228 Li S, Pan Y, Differential expression of transforming growth factor-beta1, connective tissue growth factor, phosphorylated-SMAD2/3 and phosphorylated-ERK1/2 during mouse tooth development. J Mol Histol. 2017 Dec;48(5-6):347-355
1	J:331948 Liu Z, Chen T, Bai D, Tian W, Chen Y, Smad7 Regulates Dental Epithelial Proliferation during Tooth Development. J Dent Res. 2019 Nov;98(12):1376-1385
1	J:236373 Ludtke TH, Rudat C, Wojahn I, Weiss AC, Kleppa MJ, Kurz J, Farin HF, Moon A, Christoffels VM, Kispert A, Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung. Dev Cell. 2016 Oct 24;39(2):239-253
1	J:326537 Mahmoud M, Evans I, Wisniewski L, Tam Y, Walsh C, Walker-Samuel S, Frankel P, Scambler P, Zachary I, Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract. Cardiovasc Res. 2022 Jun 29;118(8):1993-2005
1	J:95075 Molin DG, Poelmann RE, DeRuiter MC, Azhar M, Doetschman T, Gittenberger-de Groot AC, Transforming growth factor beta-SMAD2 signaling regulates aortic arch innervation and development. Circ Res. 2004 Nov 26;95(11):1109-17
1	J:205283 Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M, Programmed cell senescence during mammalian embryonic development. Cell. 2013 Nov 21;155(5):1104-18
1*	J:321553 Neupane S, Berardinelli SJ, Cameron DC, Grady RC, Komatsu DE, Percival CJ, Takeuchi M, Ito A, Liu TW, Nairn AV, Moremen KW, Haltiwanger RS, Holdener BC, O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development. Matrix Biol. 2022 Feb 12;
1	J:233662 Noda K, Mishina Y, Komatsu Y, Constitutively active mutation of ACVR1 in oral epithelium causes submucous cleft palate in mice. Dev Biol. 2016 Jul 15;415(2):306-13
1	J:134002 Pacheco MS, Reis AH, Aguiar DP, Lyons KM, Abreu JG, Dynamic analysis of the expression of the TGFbeta/SMAD2 pathway and CCN2/CTGF during early steps of tooth development. Cells Tissues Organs. 2008;187(3):199-210
1	J:235538 Tomann P, Paus R, Millar SE, Scheidereit C, Schmidt-Ullrich R, Lhx2 is a direct NF-kappaB target gene that promotes primary hair follicle placode down-growth. Development. 2016 May 1;143(9):1512-22
1*	J:248781 Wu BX, Li A, Lei L, Kaneko S, Wallace C, Li X, Li Z, Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) beta3 and is essential for mouse palatogenesis. J Biol Chem. 2017 Nov 03;292(44):18091-18097
1	J:112634 Xu X, Han J, Ito Y, Bringas P Jr, Urata MM, Chai Y, Cell autonomous requirement for Tgfbr2 in the disappearance of medial edge epithelium during palatal fusion. Dev Biol. 2006 Sep 1;297(1):238-48
1	J:197830 Zhang R, Huang H, Cao P, Wang Z, Chen Y, Pan Y, Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse. J Biol Chem. 2013 Apr 12;288(15):10275-85